Review article published from the ERA Chair and collaborators in Metabolic Engineering

Metabolic Engineering

Review article from the ERA Chair and collaborators from LanzaTech and The University of Queensland published in the top journal Metabolic Engineering provides a comprehensive overview of advances in systems metabolic engineering of autotrophic carbon oxide-fixing biocatalysts towards a circular economy. The review focuses on biochemical identification of pathways, components, and activities; redox, energy, carbon, and electron balancing; thermodynamics and fluxes; regulatory mechanisms; and genotype-phenotype links in the key chemolithoautotrophic biocatalysts acetogens and hydrogenotrophs. Aspects of genetic engineering of cell factories and industrial gas fermentation are also covered.