Recent publications

2019

Espinosa, M.I., Valgepea, K., Gonzalez Garcia, R.A., Scott, C., Pretorius, I.S., Marcellin, E., Paulsen, I.T. & Williams, T.C. Native and synthetic methanol assimilation in Saccharomyces cerevisiae. bioRxiv 717942; doi: https://doi.org/10.1101/717942

Lemgruber, R.d.S.P., Valgepea, K., Gonzalez Garcia, R.A., de Bakker, C., Palfreyman, R.W., Tappel, R., Köpke, M., Simpson, S.D., Nielsen, L.K. & Marcellin, E. A TetR-family protein activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens. bioRxiv 668756; doi: https://doi.org/10.1101/668756

Lemgruber*, R.d.S.P.*, Valgepea*, K., Tappel, R., Behrendorff, J.B., Palfreyman, R.W., Plan, M., Hodson, M.P., Simpson, S.D., Nielsen, L.K., Köpke, M. & Marcellin, E. Systems-level engineering and characterization of Clostridium autoethanogenum through heterologous production of poly-3-hydroxybutyrate (PHB). Metabolic Engineering, 53: 14-23; doi: https://doi.org/10.1016/j.ymben.2019.01.003

*joint first author

2018

Valgepea, K., Lemgruber, R.d.S.P., Abdalla, T., Binos, S., Takemori, N., Takemori, A., Tanaka, Y., Tappel, R., Köpke, M., Simpson, S.D., Nielsen, L.K. & Marcellin, E. H2 drives metabolic rearrangements in gas-fermenting Clostridium autoethanogenum. Biotechnology for Biofuels, 11:55; doi: https://doi.org/10.1186/s13068-018-1052-9

Lemgruber, R.d.S.P., Valgepea, K., Hodson, M.P., Tappel, R., Köpke, M., Simpson, S.D., Nielsen, L.K. & Marcellin, E. Quantitative analysis of tetrahydrofolate metabolites from Clostridium autoethanogenum. Metabolomics, 14:35; doi: https://doi.org/10.1007/s11306-018-1331-2

2017

Valgepea, K., Lemgruber, R.d.S.P., Meaghan, K., Palfreyman, R.W., Abdalla, T., Heijstra, B., Behrendorff, J.B., Tappel, R., Köpke, M., Simpson, S.D., Nielsen, L.K. & Marcellin, E. Maintenance of ATP homeostasis triggers metabolic shifts in gas-fermenting acetogens. Cell Systems, 4: 505-515; doi: https://doi.org/10.1016/j.cels.2017.04.008

Valgepea, K., Loi, K.Q., Behrendorff, J.B., Lemgruber, R.d.S.P., Plan, M., Hodson, M.P., Köpke, M., Nielsen, L.K. & Marcellin, E. Arginine deiminase pathway provides ATP and boosts growth of the gas-fermenting acetogen Clostridium autoethanogenum. Metabolic Engineering, 41: 202-211; doi: https://doi.org/10.1016/j.ymben.2017.04.007