Research article published from the ERA Chair and collaborators in Proceedings of the National Academy of Sciences (PNAS)

Research article from the ERA Chair and collaborators from The University of Queensland, Australia and LanzaTech published in the top journal PNAS achieves quantification of the limits of metabolic robustness that is essential for understanding cellular behaviour. The authors coupled steady-state autotrophic chemostat cultures, metabolomics, proteomics, and thermodynamic metabolic flux analysis to show that metabolic oscillations in acetogens are controlled at the thermodynamic level and coordinated through redox. This work contributes towards advancing the understanding of an industrially relevant cell factory used in gas fermentation for sustainable production of fuels and chemicals from waste feedstocks.